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Women comprised 55% of OAG, 70% of ACG, and 59% of all glaucoma in 2010.Bilateral blindness were present in 4.5 million people with OAG and 3.9 million people with ACG in 2010, rising to 5.9 and 5.3 million people in 2020, respectively [1, 2].

Therefore, ongoing ECM turnover is necessary for homeostatic maintenance of the IOP.Thus, the aim of this study was to evaluate expression level of MMP1, MMP9, MMP12, and TIMP1 in blood and aqueous humor of POAG patients compared to control group of people without any type of glaucoma diagnosed.Moreover, we compared expression levels with polymorphic variants previously determined by our team [12].Patients were excluded from the study if they were subject to any of the following conditions, which could possibly interfere with the results of the study: use of eye drops, any ocular surgeries or laser treatments performed in the past in the eye from which the specimens were to be collected, present or prior treatment with glucocorticosteroids or immunosuppressive therapy (if these treatments had not been stopped at least 1 year before the surgery and collection of specimens), use of nonsteroidal anti-inflammatory drugs (with the exception of low-dose aspirin, which had to be stopped 7 days before the surgery and collection of specimens), and prior and concurrent systemic antibiotic treatment during the last 7 days before the start of the study.The study was reviewed and approved by the local Ethics Committee (Permission number RNN/468/10/k B) and met the tenets of the Declaration of Helsinki.

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